Rett Syndrome and the Microbiome

Rett syndrome, a common neurodevelopmental disorder in girls, alters motor skills and cognition, with disruptions in digestion and metabolism frequently occurring in affected individuals. The Janine LaSalle lab, including Tianna Grant -- PREP@UCD alumna and current UCSF grad student -- have identified new pathways of the progression of Rett Syndrome, with changes in the gut microbiome and metabolism emerging prior to the onset of neurological symptoms. Further, they observed sexual dimorphism in disease progression within mouse models. For more information, see their publication in Nature Communications Biology.